Article

Microbial cancer immunotherapy reprograms hematopoiesis to enhance anti-tumor immunity

2024-03-21

Abstract excerpt

<h4>Summary</h4> Mycobacterium bovis BCG is the vaccine against tuberculosis and an immunotherapy for bladder cancer. When administered intravenously, BCG reprograms bone marrow hematopoietic stem and progenitor cells (HSPCs), leading to heterologous protection against infections. Whether HSPC-reprogramming contributes to the anti-tumor effects of BCG administered into the bladder is unknown. We demonstrate that...

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Literature Corpus work: ff4f2347-853a-587f-8239-be9966f22e68
DOI: 10.1101/2024.03.21.586166

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