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Article

Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model.

Alzheimer's research & therapy - 18 Jun 2018

Herline Krystal, Prelli Frances, Mehta Pankaj, MacMurray Claire, Goñi Fernando, Wisniewski Thomas

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by physiologically endogenous proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating as soluble oligomers and insoluble aggregates. Tau and Aβ soluble oligomers, which contain extensive β-sheet secondary structure, are thought to be the most toxic forms. The objective of this study was to determine the ability of TWF9, an...

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Source

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Identifiers

PMID: 29914551
DOI: 10.1186/s13195-018-0384-9
PMCID: PMC6006698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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