Article

Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model

2024-03-29

Abstract excerpt

Cellular senescence, characterized by expressing the cell cycle inhibitory proteins, is evident in driving age-related diseases. Senescent cells play a crucial role in the initiation and progression of tau-mediated pathology, suggesting that targeting cell senescence offers a therapeutic potential for treating tauopathy associated diseases. This study focuses on identifying non-invasive biomarkers and validating t...

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Identifiers and source

Literature Corpus work: 5bba08c4-cc41-5f36-8177-6644567ef064
DOI: 10.1101/2024.03.25.586662

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