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Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection

1 Mar 2023

Abstract excerpt

Tuberculous meningitis (TBM) is the most severe and deadly manifestation of tuberculosis. Neurological complications are observed in up to 50% of patients affected. Here, attenuated Mycobacterium bovis are injected into the cerebellum of mice, and histopathological images and cultured colonies confirm successful brain infection. Then, whole-brain tissue is dissected for 10X Genomics single-cell sequencing, and we...

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PMID: 36862557
DOI: 10.1016/j.celrep.2023.112177

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