Article

RstA Regulation of <i>Clostridioides difficile</i> Toxin Production and Sporulation in Phenotypically Diverse Strains

2019-09-18

Abstract excerpt

<h4>ABSTRACT</h4> The anaerobic spore-former, Clostridioides difficile , causes significant diarrheal disease in humans and other mammals. Infection begins with the ingestion of dormant spores which subsequently germinate within the host gastrointestinal tract. Here, the vegetative cells proliferate and secrete two exotoxins, TcdA and TcdB, which cause disease symptoms. Although spore formation and toxin product...

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Literature Corpus work: 932cfd4f-6cb1-58fd-92cd-8f900b8b2423
DOI: 10.1101/774125

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