Article

Glucosyltransferase-dependent and independent effects of <i>Clostridioides difficile</i> toxins during infection

2021-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threatening toxic megacolon. CDI is mediated by two large homologous protein toxins, TcdA and TcdB, that bind and hijack receptors to enter host cells whe...

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Literature Corpus work: 534cd171-0778-52e9-9862-c8b98c6652ad
DOI: 10.1101/2021.09.22.460915

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