Article

Chromatin dynamics identifies 78 genes at loci associated with elevated intraocular pressure and primary open-angle glaucoma

2026-03-16

Abstract excerpt

<h4>SUMMARY</h4> Primary open-angle glaucoma (POAG) is a chronic neurodegenerative disorder, and elevated intraocular pressure (IOP) represents the major, and only modifiable, risk factor for the disease. We modeled increased IOP by treating three primary human trabecular meshwork (TM) cell strains with dexamethasone, then generated a high-resolution map of promoter-centered chromatin contacts and regulatory modu...

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Literature Corpus work: a3f4d835-8de6-59eb-a7d8-1ae2f4404560
DOI: 10.64898/2026.03.12.711121

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