Article

Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insight

2025-08-13

Abstract excerpt

<h4>SUMMARY</h4> Adverse drug reactions are a frequent cause of worldwide morbidity and mortality. Glucocorticoids (GCs), commonly used to treat inflammatory diseases, alter gene expression with both beneficial and adverse consequences. When used in the eye, GCs cause steroid-induced ocular hypertension (SIOH) in 30-50% of patients, leading to steroid-induced glaucoma. Evidence suggests that predisposition to SIO...

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Literature Corpus work: f291dacd-0451-5048-8c7d-e5bc022e8782
DOI: 10.1101/2025.08.11.25333245

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