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Article

Linking Iris Cis-Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics.

Investigative ophthalmology & visual science - 2 Dec 2024

Li Jiaying, Chen Yun, Wang Wenbin, Zhang Ye, Su Guangsong, Wang Sean K, Zhang Yuanyuan, Yao Yilong, Wu Shen, Lu Wange, Zhang Kunlin, Qiao Chunyan, Li Shuning, Li Hengtong, Cheng Ching-Yu, Liu Yuwen, Wang Ningli

Abstract excerpt

Purpose: To elucidate the genetic basis of primary angle-closure glaucoma (PACG) by identifying pathogenic tissue and critical tissue-specific variants. Methods: The correlations among PACG susceptibility, axial length (AL), and anterior chamber depth (ACD) were evaluated using meta-analyses. Propensity score matching was utilized on 2161 participants from the Handan Eye Study to determine the risk factors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39652066
DOI: 10.1167/iovs.65.14.18
PMCID: PMC11629910

Genes

ACD
PLEKHA7

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