Article
A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.
Nature communications - 11 Jun 2018
Choquet Hélène, Paylakhi Seyyedhassan, Kneeland Stephen C, Thai Khanh K, Hoffmann Thomas J, Yin Jie, Kvale Mark N, Banda Yambazi, Tolman Nicholas G, Williams Pete A, Schaefer Catherine, Melles Ronald B, Risch Neil, John Simon W M, Nair K Saidas, Jorgenson Eric
Abstract excerpt
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, especially in African-Americans who have a higher risk for developing POAG. We conduct a multiethnic genome-wide association study (GWAS) of POAG in the GERA cohort, with replication in the UK Biobank (UKB), and vice versa, GWAS in UKB with replication in GERA. We identify 24...
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