Article

Time-dependent Glucocorticoid-Induced Transcriptomic Changes in Human Trabecular Meshwork and Schlemm’s Canal

2026-01-01

Abstract excerpt

<h4>Purpose</h4> To identify the transcriptomic changes induced by dexamethasone (DEX) in trabecular meshwork (TM) and Schlemm’s canal endothelial (SCE) cells with RNA-sequencing (RNA-seq). <h4>Methods</h4> Human TM (n=10) and SCE cell strains (n=5) were isolated from healthy donor eyes and exposed to DEX 100nM and vehicle (control). Three DEX exposure times were evaluated: 1-hour, 6-hours, and 2 days. RNA-seq w...

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Literature Corpus work: 2f666d52-3509-563f-a7ea-e472286cc005
DOI: 10.64898/2025.12.31.696882

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