Article

Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

2020-03-17

Abstract excerpt

Despite increasing numbers of effective anti-cancer therapies, successful treatment is limited by the development of drug resistance. While the contribution of genetic factors to drug resistance is undeniable, little is known about how drug-sensitive cells first evade drug action to proliferate in drug. Here we track the response of thousands of single melanoma cells to BRAF inhibitors and show that a subset escap...

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Identifiers and source

Literature Corpus work: a3ef6859-cf6f-51ab-9cb8-0d5d64db4510
DOI: 10.1101/2020.03.15.992982

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