Article

Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

2023-03-21

Abstract excerpt

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway and many targeted inhibitors now exist for clinical use, but drug resistance remains a major issue. We recently showed that BRAF-driven melanoma cells treated with BRAF inhibitors can non-genetically adapt to drug within 3-4 days to escape quiescence and resume slow proliferation. Here we show that this phenomeno...

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Identifiers and source

Literature Corpus work: 2b319171-7fe0-5695-8769-4e3486dcd7e9
DOI: 10.1101/2023.03.17.533211

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