Article

Treatment Resistance to Melanoma Therapeutics on a Single Cell Level

2022-08-09

Abstract excerpt

Therapy targeting the BRAF-MEK cascade created a treatment revolution for patients with BRAF mutant advanced melanoma. Unfortunately, 80% patients treated will progress by 5 years follow-up. Thus, it is imperative we study mechanisms of melanoma progression and therapeutic resistance. We created a scRNA (single cell RNA) atlas of 128,230 cells from 18 tumors across the treatment spectrum, discovering melanoma cell...

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Literature Corpus work: c7dfdaf3-f2ba-5f47-99d4-10b5d72c0afd
DOI: 10.21203/rs.3.rs-1836883/v1

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