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Article

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.

Molecular systems biology - 9 Jan 2017

Fallahi-Sichani Mohammad, Becker Verena, Izar Benjamin, Baker Gregory J, Lin Jia-Ren, Boswell Sarah A, Shah Parin, Rotem Asaf, Garraway Levi A, Sorger Peter K

Abstract excerpt

Treatment of BRAF-mutant melanomas with MAP kinase pathway inhibitors is paradigmatic of the promise of precision cancer therapy but also highlights problems with drug resistance that limit patient benefit. We use live-cell imaging, single-cell analysis, and molecular profiling to show that exposure of tumor cells to RAF/MEK inhibitors elicits a heterogeneous response in which some cells die, some arrest, and the...

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Identifiers

PMID: 28069687
DOI: 10.15252/msb.20166796
PMCID: PMC5248573

Genes

NGFR
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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