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Article

Drug tolerance to target therapy in melanoma revealed at single cell level: What next?

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2020

Liguoro Domenico, Fattore Luigi, Mancini Rita, Ciliberto Gennaro

Abstract excerpt

Drug resistance strongly impairs the efficacy of virtually every kind of anticancer therapy. This phenomenon is commonly fueled by intrinsic or acquired mechanisms. In this mini-review, focusing on BRAF-mutated melanoma as prototypical example, we analyze how recent studies that make use of single cell analysis identify the involvement of distinct transcriptional trajectories as the common thread at the basis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33007433
DOI: 10.1016/j.bbcan.2020.188440

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