Article

Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition

2024-02-21

Abstract excerpt

A major contributor to poor sensitivity to anti-cancer kinase inhibitor therapy is drug-induced cellular adaptation, whereby remodeling of signaling and gene regulatory networks permits a drug-tolerant phenotype. Here, we resolve the scale and kinetics of critical subcellular events following oncogenic kinase inhibition and preceding cell cycle re-entry, using mass spectrometry-based phosphoproteomics and RNA sequ...

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Literature Corpus work: 3259e74d-b174-5d53-862e-5a9ee1cf20ea
DOI: 10.1101/2024.02.19.581004

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