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Article

Treatment resistance to melanoma therapeutics on a single cell level.

Scientific reports - 19 Sept 2024

Yao Lijun, Krasnick Bradley A, Bi Ye, Sethuraman Sunantha, Goedegebuure Simon, Weerasinghe Amila, Wetzel Chris, Gao Qingsong, Oyedeji Abimbola, Mudd Jacqueline, Wyczalkowski Matthew A, Wendl Michael, Ding Li, Fields Ryan C

Abstract excerpt

Therapy targeting the BRAF-MEK cascade created a treatment revolution for patients with BRAF mutant advanced melanoma. Unfortunately, 80% patients treated will progress by 5 years follow-up. Thus, it is imperative we study mechanisms of melanoma progression and therapeutic resistance. We created a scRNA (single cell RNA) atlas of 128,230 cells from 18 tumors across the treatment spectrum, discovering melanoma...

Topics

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Drug Resistance, Neoplasm
Melanoma
Metformin
Phosphoglycerate Kinase
Programmed Cell Death 1 Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Single-Cell Analysis

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Open in PubMed Open full text

Identifiers

PMID: 39300183
DOI: 10.1038/s41598-024-72255-9
PMCID: PMC11413001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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