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Article

DnaJC7 in Amyotrophic Lateral Sclerosis.

International journal of molecular sciences - 7 Apr 2022

Dilliott Allison A, Andary Catherine M, Stoltz Meaghan, Petropavlovskiy Andrey A, Farhan Sali M K, Duennwald Martin L

Abstract excerpt

Protein misfolding is a common basis of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Misfolded proteins, such as TDP-43, FUS, Matrin3, and SOD1, mislocalize and form the hallmark cytoplasmic and nuclear inclusions in neurons of ALS patients. Cellular protein quality control prevents protein misfolding under normal conditions and, particularly, when cells experience protein...

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Identifiers

PMID: 35456894
DOI: 10.3390/ijms23084076
PMCID: PMC9025444

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