Article
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
Nature communications - 9 Sept 2021
Hou Zhiqiang, Wydorski Pawel M, Perez Valerie A, Mendoza-Oliva Aydé, Ryder Bryan D, Mirbaha Hilda, Kashmer Omar, Joachimiak Lukasz A
Abstract excerpt
Molecular chaperones, including Hsp70/J-domain protein (JDP) families, play central roles in binding substrates to prevent their aggregation. How JDPs select different conformations of substrates remains poorly understood. Here, we report an interaction between the JDP DnaJC7 and tau that efficiently suppresses tau aggregation in vitro and in cells. DnaJC7 binds preferentially to natively folded wild-type tau,...
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