Article

Mechanical licensing of functional dendritic cell states for enhanced T cell priming

2026-05-21

Abstract excerpt

The plasticity of dendritic cell (DC) functional state is a major hurdle in DC therapy, yet how DCs acquire distinct states independent of ontogeny remains poorly understood. Here, we demonstrate that changes in matrix stress relaxation mechanically educate DCs to adopt distinct, persistent functional states even after the removal of mechanical cues. Stem cell-derived DCs cultured in a fast-relaxing environment ex...

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Literature Corpus work: a3d22790-9d70-563d-93aa-98801ac20abd
DOI: 10.64898/2026.05.19.725170

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