Article

The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces

2024-02-02

Abstract excerpt

Obesity is a major public health crisis given its rampant growth and association with an increased risk for cancer. Interestingly, patients with obesity tend to have an increased tumor burden and decreased T-cell function. It remains unclear how obesity compromises T-cell mediated immunity. To address this question, we modeled the adipocyte niche using the secretome released from adipocytes as well as the niche of...

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Identifiers and source

Literature Corpus work: 42580646-6129-5096-b44b-35df4544e389
DOI: 10.1101/2024.01.31.578101

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