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Article

Tunable wrinkled topographies direct dendritic cell maturation and immune phenotypes.

Acta biomaterialia - 1 Mar 2026

Chavda Ajay, Zhou Xingwu, Tokmedash Mohammad Asadi, Moon James J, Min Jouha

Abstract excerpt

Dendritic cells (DCs) are potent regulators of immunity with therapeutic potential in cancer, autoimmune disorders, and implant tolerance. However, clinical translation is limited by poor scalability, limited survival/retention after delivery, and difficulty controlling DC immune responses. Biomaterials have been explored to address these challenges, but the role of surface topography in DC regulation remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41478520
DOI: 10.1016/j.actbio.2025.12.050
PMCID: PMC12997553

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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