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Article

Injection site fibroblasts acquire antigen-presenting cell properties and modulate mRNA-LNP immune responses

2026-08-28

Abstract excerpt

<title>Abstract</title> <p>mRNA lipid nanoparticle (LNP) vaccines have revolutionized infectious disease prevention, yet mechanisms driving immunogenicity at the site of injection remain only partially understood. Through multi-tissue transcriptomic profiling in mice, we confirmed muscle as a prominent hub of vaccine-induced activity, with pronounced localized transcriptional reprogramming. Post-vaccination analy...

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Identifiers and source

Literature Corpus work
d6c2531f-1fcf-5688-8909-20adf9dafb9d
DOI
10.21203/rs.3.rs-10629309/v1
Open publication

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Injection site fibroblasts acquire antigen-presenting cell properties and modulate mRNA-LNP immune responsesDOI 10.21203/rs.3.rs-10629309/v1
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