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Article

Biomaterial-assisted local oxygenation safeguards the prostimulatory phenotype and functions of human dendritic cells in hypoxia.

Frontiers in immunology - 1 Jan 2023

Bhatt Khushbu, Nukovic Alexandra, Colombani Thibault, Bencherif Sidi A

Abstract excerpt

Dendritic cells (DCs), professional antigen-presenting cells, function as sentinels of the immune system. DCs initiate and fine-tune adaptive immune responses by presenting antigenic peptides to B and T lymphocytes to mount an effective immune response against cancer and pathogens. However, hypoxia, a condition characterized by low oxygen (O2) tension in different tissues, significantly impacts DC functions,...

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Identifiers

PMID: 38169677
DOI: 10.3389/fimmu.2023.1278397
PMCID: PMC10758617

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