Article

Spatio-temporal Force Patterns Reveal a Mechanical Set Point in Early T Cell Activation

2022-02-11

Abstract excerpt

Mechanical forces are increasingly recognized as critical regulators of T cell activation, yet their earliest dynamics remain poorly resolved. Here, we use traction force microscopy on ultra-soft, antigen-presenting-cell-like polyacrylamide substrates to quantify the first 15 minutes of force generation by Jurkat and primary human CD4⁺ T cells under controlled activating conditions. By combining time-resolved stre...

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Literature Corpus work: 823c07b1-e44c-5db7-b1f5-1356c86e3f23
DOI: 10.1101/2022.02.11.480084

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