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Article

Differential programming of B cells in AID deficient mice.

PloS one - 1 Jan 2013

Hogenbirk Marc A, Heideman Marinus R, Velds Arno, van den Berk Paul C M, Kerkhoven Ron M, van Steensel Bas, Jacobs Heinz

Abstract excerpt

The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes. Besides these Ig specific activities in B cells, AID has been implicated in active DNA demethylation in non-B cell systems. We here determined a potential role of AID as an...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23922811
DOI: 10.1371/journal.pone.0069815
PMCID: PMC3726761

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