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Article

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.

Cell reports - 30 Aug 2016

Hedl Matija, Yan Jie, Abraham Clara

Abstract excerpt

Interferon regulatory factor 5 (IRF5) regulates inflammatory M1 macrophage polarization, and disease-associated IRF5 genetic variants regulate pattern-recognition-receptor (PRR)-induced cytokines. PRR-stimulated macrophages and M1 macrophages exhibit enhanced glycolysis, a central mediator of inflammation. We find that IRF5 is needed for PRR-enhanced glycolysis in human macrophages and in mice in vivo. Upon...

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Share to Adjuvants, Immunologic
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Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factors

Share to Interleukin-1 Receptor-Associated Kinases

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Source

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Identifiers

PMID: 27545875
DOI: 10.1016/j.celrep.2016.07.060
PMCID: PMC5165654

Genes

IRAK1
NOD2
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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