Article
The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease.
The Journal of experimental medicine - 7 Mar 2016
Shirai Tsuyoshi, Nazarewicz Rafal R, Wallis Barbara B, Yanes Rolando E, Watanabe Ryu, Hilhorst Marc, Tian Lu, Harrison David G, Giacomini John C, Assimes Themistocles L, Goronzy Jörg J, Weyand Cornelia M
Abstract excerpt
Abnormal glucose metabolism and enhanced oxidative stress accelerate cardiovascular disease, a chronic inflammatory condition causing high morbidity and mortality. Here, we report that in monocytes and macrophages of patients with atherosclerotic coronary artery disease (CAD), overutilization of glucose promotes excessive and prolonged production of the cytokines IL-6 and IL-1β, driving systemic and tissue...
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