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Article

Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status.

Thrombosis and haemostasis - 1 Nov 2021

Tsokanos Foivos-Filippos, Muley Carolin, Khani Sajjad, Hass Daniela, Fleming Thomas, Wolff Gretchen, Bartelt Alexander, Nawroth Peter, Herzig Stephan

Abstract excerpt

Metabolic complications in diabetic patients are driven by a combination of increased levels of nutrients and the presence of a proinflammatory environment. Methylglyoxal (MG) is a toxic byproduct of catabolism and has been strongly associated with the development of such complications. Macrophages are key mediators of inflammatory processes and their contribution to the development of metabolic complications has...

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PMID: 33966256
DOI: 10.1055/s-0041-1726346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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