Article

Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Proteome-wide association studies (PWAS) typically link genetically predicted protein levels to disease using cis-pQTLs, which can be limited by low cis-heritability for disease-critical genes under negative selection and by tagging due to co-regulation among nearby genes. Trans-pQTLs provide complementary information when large sample sizes are available to detect weak polygenic effect...

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Literature Corpus work: a3b588e5-eb01-5c77-b8f7-598a574bfbd4
DOI: 10.21203/rs.3.rs-9477232/v1

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