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Article

Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits.

Nature genetics - 1 Jan 2026

Li Jinghui, Li Yang I, Liu Xuanyao

Abstract excerpt

Most genetic variants influence complex traits by affecting gene regulation. Yet, despite comprehensive catalogs of molecular quantitative trait loci (QTLs), linking trait-associated variants to biological functions remains difficult. By re-analyzing large maps of protein QTLs (pQTLs), we found that genes with trans-pQTLs but no cis-pQTLs are under strong selective constraints and are particularly informative in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41501544
DOI: 10.1038/s41588-025-02449-y
PMCID: PMC12807863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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