Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.

American journal of human genetics - 7 Mar 2024

Wittich Henry, Ardlie Kristin, Taylor Kent D, Durda Peter, Liu Yongmei, Mikhaylova Anna, Gignoux Chris R, Cho Michael H, Rich Stephen S, Rotter Jerome I, Manichaikul Ani, Im Hae Kyung, Wheeler Heather E

Abstract excerpt

Regulation of transcription and translation are mechanisms through which genetic variants affect complex traits. Expression quantitative trait locus (eQTL) studies have been more successful at identifying cis-eQTL (within 1 Mb of the transcription start site) than trans-eQTL. Here, we tested the cis component of gene expression for association with observed plasma protein levels to identify cis- and trans-acting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome-Wide Association Study
Share to Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Proteome

Share to Quantitative Trait Loci

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 38320554
DOI: 10.1016/j.ajhg.2024.01.006
PMCID: PMC10940016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.PMID 38320554Read ↗

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read ↗

Mapping the genetic architecture of gene regulation in whole blood.Semantic proximity Read ↗

Local genetic effects on gene expression across 44 human tissuesSemantic proximity Read ↗

Imputed gene associations identify replicable <i>trans</i> -acting genes enriched in transcription pathways and complex traitsSemantic proximity Read ↗

Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation.Semantic proximity Read ↗

The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes.Semantic proximity Read ↗

Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases.Semantic proximity Read ↗

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of DiseasesSemantic proximity Read ↗

Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.Semantic proximity Read ↗

Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT studySemantic proximity Read ↗

Types of cis- and trans-gene regulation of expression quantitative trait loci across human tissuesSemantic proximity Read ↗

Protein prediction for trait mapping in diverse populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.