Article

Functionally informed cis and trans proteome-wide association studies prioritize disease-critical genes

2026-04-27

Abstract excerpt

Proteome-wide association studies (PWAS) typically link genetically predicted protein levels to disease using cis-pQTLs, which can be limited by low cis-heritability for disease-critical genes under negative selection and by tagging due to co-regulation among nearby genes. Trans-pQTLs provide complementary information when large sample sizes are available to detect weak polygenic effects, enabling associations bet...

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Literature Corpus work: 8f500316-e25e-5eb9-8cd3-3b2170b6cdde
DOI: 10.64898/2026.04.24.26351667

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