Article
Mapping the proteo-genomic convergence of human diseases.
Science (New York, N.Y.) - 12 Nov 2021
Pietzner Maik, Wheeler Eleanor, Carrasco-Zanini Julia, Cortes Adrian, Koprulu Mine, Wörheide Maria A, Oerton Erin, Cook James, Stewart Isobel D, Kerrison Nicola D, Luan Jian'an, Raffler Johannes, Arnold Matthias, Arlt Wiebke, O'Rahilly Stephen, Kastenmüller Gabi, Gamazon Eric R, Hingorani Aroon D, Scott Robert A, Wareham Nicholas J, Langenberg Claudia
Abstract excerpt
Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic associations for 3892 plasma proteins to create a cis-anchored gene-protein-disease map of 1859 connections that highlights strong cross-disease biological convergence. This proteo-genomic map provides a framework to connect etiologically related diseases,...
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