Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes.

Genome medicine - 12 Dec 2022

Yang Chengran, Fagan Anne M, Perrin Richard J, Rhinn Herve, Harari Oscar, Cruchaga Carlos

Abstract excerpt

BACKGROUND: Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR) studies have been mainly focused on plasma proteomes. Previous MR studies using the brain proteome only reported...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome-Wide Association Study
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Proteome

Share to Proteomics

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 36510323
DOI: 10.1186/s13073-022-01140-9
PMCID: PMC9746220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes.PMID 36510323Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.Semantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseasesSemantic proximity Read ↗

Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traitsSemantic proximity Read ↗

Genetic mechanisms of 184 neuro-related proteins in human plasmaSemantic proximity Read ↗

Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traitsSemantic proximity Read ↗

Uncovering bi-directional causal relationships between plasma proteins and psychiatric disorders: A proteome-wide study and directed network analysisSemantic proximity Read ↗

Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data.Semantic proximity Read ↗

Colocalization and discordance between plasma and brain protein quantitative trait lociSemantic proximity Read ↗

Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysisSemantic proximity Read ↗

Multi-Omics Integration Analysis Pinpoint Proteins Influencing Brain Structure and Function: Toward Drug Targets and Neuroimaging Biomarkers for Neuropsychiatric Disorders.Semantic proximity Read ↗

Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity Read ↗

A Mendelian randomization study identifies proteins involved in neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.