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Article

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.

Neurobiology of aging - 1 Aug 2013

Giraldo Margarita, Lopera Francisco, Siniard Ashley L, Corneveaux Jason J, Schrauwen Isabelle, Carvajal Julian, Muñoz Claudia, Ramirez-Restrepo Manuel, Gaiteri Chris, Myers Amanda J, Caselli Richard J, Kosik Kenneth S, Reiman Eric M, Huentelman Matthew J

Abstract excerpt

Recent evidence suggests that rare genetic variants within the TREM2 gene are associated with increased risk of Alzheimer's disease. TREM2 mutations are the genetic basis for a condition characterized by polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) and an early-onset dementia syndrome. TREM2 is important in the phagocytosis of apoptotic neuronal cells by microglia in the...

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Identifiers

PMID: 23582655
DOI: 10.1016/j.neurobiolaging.2013.02.016
PMCID: PMC3830921

Genes

TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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