Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.

Frontiers in immunology - 1 Jan 2020

Korvatska Olena, Kiianitsa Kostantin, Ratushny Alexander, Matsushita Mark, Beeman Neal, Chien Wei-Ming, Satoh Jun-Ichi, Dorschner Michael O, Keene C Dirk, Bammler Theo K, Bird Thomas D, Raskind Wendy H

Abstract excerpt

The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer's disease (AD). To characterize processes affected by R47H, we performed an integrative network analysis of genes expressed in brains of AD patients with R47H, sporadic AD without the variant, and patients with polycystic lipomembranous osteodysplasia with sclerosing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Immunity

Share to Loss of Function Mutation

Share to Membrane Glycoproteins

Share to Phagocytosis

Share to Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 33101276
DOI: 10.3389/fimmu.2020.559342
PMCID: PMC7546799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.PMID 33101276Read ↗

TREM2 R47H exacerbates immune response in Alzheimer’s disease brainSemantic proximity Read ↗

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.Semantic proximity Read ↗

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.Semantic proximity Read ↗

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.Semantic proximity Read ↗

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.Semantic proximity Read ↗

Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.Semantic proximity Read ↗

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.Semantic proximity Read ↗

IPSC-derived neuronal cultures expressing the Alzheimer’s disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory networkSemantic proximity Read ↗

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.Semantic proximity Read ↗

Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseasesSemantic proximity Read ↗

<i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditionsSemantic proximity Read ↗

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.