Article

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

2020-11-17

Abstract excerpt

Abnormal numerical and structural chromosome content is frequently found in human cancer. To test the role of aneuploidy in tumor initiation and progression, we compared tumor development in mice with chronic chromosome instability (CIN) induced by inactivation of the spindle assembly checkpoint (produced by Mad2 deficiency) and mice with transient CIN through transiently increased expression of polo-like kinase 4...

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Literature Corpus work: 9c59ce65-f573-500b-98e6-d02b41d6c7df
DOI: 10.1101/2020.11.17.387753

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