Article

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer’s disease

2023-11-20

Abstract excerpt

Recent research revealed that Tau plays critical roles in various neuronal functions. Our previous work demonstrated that destabilization and nuclear delocalization of Tau can alter the expression of glutamatergic genes, thereby mediating early neuronal damage. Upon analysing gene coexpression of AD temporal regions at different stages and the transcriptional output in differentiated neuroblastoma cells, we discov...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a36df900-b10b-52b6-8206-4dbc4f5ba6bb
DOI: 10.1101/2023.11.17.567548

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tau alters global gene expression affecting chromatin in the early stages of Alzheimer’s diseaseDOI 10.1101/2023.11.17.567548Read

Phospho-Tau and Chromatin Landscapes in Early and Late Alzheimer’s DiseaseSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s diseaseSemantic proximity Read

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's diseaseSemantic proximity Read

Epigenetic Mechanisms in Alzheimer's DiseaseSemantic proximity Read

Epigenetic mechanisms in Alzheimer's disease.Semantic proximity Read

Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer’s DiseaseSemantic proximity Read

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brainsSemantic proximity Read

Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexesSemantic proximity Read

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologySemantic proximity Read

Advances in epigenetics and epigenomics for neurodegenerative diseases.Semantic proximity Read

Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disordersSemantic proximity Read

The Role of H3K9 Acetylation and Gene Expression in Different Brain Regions of Alzheimer’s Disease PatientsSemantic proximity Read