Article

Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes

2021-07-16

Abstract excerpt

Tau protein is a known contributor in several neurodegenerative diseases, including Alzheimer ‘s disease (AD) and frontotemporal dementia (FTD). It is well-established that tau forms pathological aggregates and fibrils in these diseases. Tau has been observed within the nuclei of neurons, but there is a gap in understanding regarding the mechanism by which tau modulates transcription. We are interested in the P301...

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Literature Corpus work: 54944abd-2f7b-5238-aec2-6f480f949070
DOI: 10.1101/2021.07.16.452616

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