Article

Antigenic variation by switching inter-chromosomal interactions with an RNA splicing locus in trypanosomes

2020-01-28

Abstract excerpt

Highly selective gene expression is a key requirement for antigenic variation in several pathogens, allowing evasion of host immune responses and maintenance of persistent infections. African trypanosomes, parasites that cause lethal diseases in humans and livestock, employ an antigenic variation mechanism that involves monogenic antigen expression from a pool of >2500 antigen coding genes. In other eukaryotes, th...

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Literature Corpus work: a36cb42a-325b-52fd-a5d6-4ad6a53753d3
DOI: 10.1101/2020.01.27.921452

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