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Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei

25 Jul 2022

Abstract excerpt

Variant surface glycoprotein (VSG) coats bloodstream form Trypanosoma brucei parasites, and monoallelic VSG expression underpins the antigenic variation necessary for pathogenicity. One of thousands of VSG genes is transcribed by RNA polymerase I in a singular nuclear structure called the expression site body (ESB), but how monoallelic VSG transcription is achieved remains unclear. Using a localization screen of...

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PMID: 35879525
DOI: 10.1038/s41564-022-01175-z

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