3D genome organization drives gene expression in trypanosomes

Abstract excerpt

In trypanosomes —eukaryotic unicellular pathogens that cause disabling human and animal diseases— very few transcriptional regulatory elements have been described and it is largely accepted that they regulate gene expression mainly post-transcriptionally. In this regard, the role of the spatial organization of the genome on gene expression and vice versa remains practically unexplored. The genome of these parasite...

Topics

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• Glycosylation and Glycoproteins Research
• Invertebrate Immune Response Mechanisms
• Malaria Research and Control
• Plant Virus Research Studies
• Research on Leishmaniasis Studies
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• Trypanosoma species research and implications

Identifiers and source

Literature Corpus work

550cda84-4016-5011-9ff2-b97431679678

DOI

10.1101/2023.04.01.535209