Article

RibonucleaseH1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion

2018-07-03

Abstract excerpt

Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a crucial host immune evasion strategy that is catalysed both by transcription and recombination reactions, each operating within specialised telomeric VSG expression sites (ES). VSG switching is likely triggered by events focused on the single actively transcribed ES, from a repertoire of around 15, but the nature of such events i...

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Literature Corpus work: d5b40a87-335e-582e-a5e9-07a2525d2fbc
DOI: 10.1101/361451

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