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Article

Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes

2025-05-25

Abstract excerpt

Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, which they periodically switch throughout an infection. Co-transcribed with the active- VSG within a specialised nuclear body are expression-site-associated-genes ( ESAGs ), involved in important host-parasite interac...

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Literature Corpus work
9fae0eaf-d47e-5418-b7e1-eee46f176420
DOI
10.1101/2025.05.24.654301
Open publication

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Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomesDOI 10.1101/2025.05.24.654301
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