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VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

25 May 2016

Abstract excerpt

Allelic exclusion underpins antigenic variation and immune evasion in African trypanosomes. These bloodstream parasites use RNA polymerase-I (pol-I) to transcribe just one telomeric variant surface glycoprotein (VSG) gene at a time, producing superabundant and switchable VSG coats. We identified trypanosome VSG exclusion-1 (VEX1) using a genetic screen for defects in telomere-exclusive expression. VEX1 was...

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PMID: 27226299
DOI: 10.1073/pnas.1600344113

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