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Genome organization and DNA accessibility control antigenic variation in trypanosomes

16 Oct 2018

Abstract excerpt

Abstract Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to evade the immune responses of their hosts. These include antigenic variation, through which an infecting organism prevents clearance by periodically altering the identity of proteins that are visible to the immune system of the host 1 . Antigenic variation requires large reservoirs of immunologically diverse...

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PMID: 30333624
DOI: 10.1038/s41586-018-0619-8

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