Article
An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome.
Nature communications - 11 Dec 2023
Faria Joana R C, Tinti Michele, Marques Catarina A, Zoltner Martin, Yoshikawa Harunori, Field Mark C, Horn David
Abstract excerpt
UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG exclusion-factor-2 (VEX2), a UPF1-related protein in the African trypanosome. We show that VEX2 associates with chromatin specifically at the single active VSG expression site on chromosome 6, forming an allele-selective connection, via...
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