Article

Continuous inhibition of Sonic hedgehog signaling effectively leads to differentiation of human-induced pluripotent stem cells into functional insulin-producing β cells

2020-04-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Human-induced pluripotent stem cell (iPSC)-derived insulin-producing cells (IPCs) can be used for islet cell transplantation in type 1 diabetic patients and as patient-specific cells for the development of novel anti-diabetic drugs. Therefore, it is necessary develop a method for generating functional IPCs from iPSCs and simplifying the stepwise protocol. <bold>...

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Literature Corpus work: a360d676-ce72-5f3a-b616-8ff96c4305fb
DOI: 10.21203/rs.3.rs-24676/v1

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